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Genome Biol. 2004;5(3):211. Epub 2004 Feb 27.

Transcription-coupled mutagenesis by the DNA deaminase AID.

Author information

  • 1Department of Immunology, University of Washington Medical School, 1959 NE Pacific Street, Seattle, WA 98195-7650, USA.

Abstract

Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.

PMID:
15003109
PMCID:
PMC395756
DOI:
10.1186/gb-2004-5-3-211
[PubMed - indexed for MEDLINE]
Free PMC Article
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