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J Pediatr. 2004 Mar;144(3):397-9.

The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection.

Author information

1
Department of Pediatrics, National Taiwan University Hospital, and the Department of Pediatrics, Cardinal Tien Hospital, Taipei, Taiwan. mhchang@ha.mc.ntu.edu.tw

Abstract

We prospectively followed 426 children with chronic hepatitis B virus infection. During 6250 person-years, 2 boys developed hepatocellular carcinoma, with an incidence of 32 per 100,000 person-years. Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma.

PMID:
15001956
DOI:
10.1016/j.jpeds.2003.11.022
[Indexed for MEDLINE]
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