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Pharmacol Rev. 2004 Mar;56(1):149-57.

International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor.

Author information

1
Centre National de la Recherche Scientifique UMR 7131, Hôpital Broussais, Bâtiment Les Mariniers, Paris, France. charlesbrink@hotmail.com

Abstract

Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that have been intimately linked with cellular migration. These metabolites are not only potent chemotaxins but also elicit oxygen radical production as well as induce secretory events in different cells. The most potent native ligand reported is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), and the cell membrane receptor activated has now been cloned. This receptor is distinct from those receptors activated by either the prostaglandins or the leukotrienes. The purpose of this review is to briefly summarize the molecular evidence and highlight the significance of this receptor. In addition, an official nomenclature for this oxoeicosanoid receptor is proposed.

PMID:
15001665
DOI:
10.1124/pr.56.1.4
[Indexed for MEDLINE]
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