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Microb Pathog. 2004 Apr;36(4):205-9.

Gingipain adhesin domains mediate Porphyromonas gingivalis adherence to epithelial cells.

Author information

1
Department of Molecular Genetics, The Forsyth Institute, 140 Fenway, Boston, MA 02115, USA.

Abstract

Porphyromonas gingivalis, a Gram-negative oral anaerobe, interacts with epithelium lining the gingival sulcus. Continuing our studies on the role of gingipain cysteine proteinases in P. gingivalis adherence to epithelial cells, we showed that antibody raised to the recombinant adhesin domain of arg-gingipain A blocked bacterial attachment, providing new additional evidence that P. gingivalis adherence to epithelial cells is mediated by gingipain adhesin peptides.

PMID:
15001226
DOI:
10.1016/j.micpath.2003.12.001
[Indexed for MEDLINE]

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