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J Med Chem. 2004 Mar 11;47(6):1319-21.

Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor.

Author information

1
GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USA. katherine.l.widdowson@gsk.com

Abstract

N,N'-Diarylureas were prepared, and the structure-activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, which in addition was shown to be functionally active both in vitro against human neutrophils and in vivo in rabbit models of ear edema and neutropenia.

PMID:
14998320
DOI:
10.1021/jm034248l
[Indexed for MEDLINE]

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