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Biochim Biophys Acta. 2004 Mar 1;1644(2-3):159-68.

Control of proliferation by Bcl-2 family members.

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INSERM U503, Centre d'étude et de Recherche en Virologie et Immunologie, 21 Avenue Tony Garnier 69365 Lyon Cedex 07, France.


The anti-proliferative effect of Bcl-2 acts mainly at the level of the G0/G1 phase of the cell cycle. Deletions and point mutations in the bcl-2 gene show that the anti-proliferative activity of Bcl-2, can in some cases, be dissociated from its anti-apoptotic function. This indicates that the effect of Bcl-2 on cell cycle progression can be a direct effect and not only a consequence of its anti-apoptotic activity. Bcl-2 appears to mediate its anti-proliferative effect by acting on both signal transduction pathways (NFAT, ERK) and on specific cell cycle regulators (p27, p130).

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