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Transfusion. 2004 Mar;44(3):407-9.

The molecular basis of the Rhesus antigen Ew.

Author information

1
Institute for Medical Microbiology, Immunology and Hygiene, Academic Hospital Munich-Schwabing, K├Âlner Platy 1, D-80804 Munich, Germany. mikrobiologie@kms.mhn.de

Abstract

BACKGROUND:

The Rhesus antigen Ew (ISBT designation 004 011) was first described in 1955. It is defined by a specific antibody, but its molecular genetic basis has not yet been resolved.

STUDY DESIGN AND METHODS:

Two individuals serologically characterized to express the rare Rhesus antigen Ew were analyzed by sequencing of all 10 exons of the RHCE gene.

RESULTS:

A nucleotide exchange at position 500 (T500A) resulting in a Met167Lys amino acid substitution was found in both individuals. Moreover, we show that an individual carrying the Ew antigen is capable to produce an alloantibody against the wild-type E antigen.

CONCLUSION:

The single-point mutation T500A in exon 4 of the RHCE gene is a molecular basis of the rare Rhesus antigen Ew.

[Indexed for MEDLINE]

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