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Eur J Drug Metab Pharmacokinet. 1992 Jan-Mar;17(1):39-44.

Comparative bioavailability of Silipide, a new flavanolignan complex, in rats.

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1
Inverni della Beffa Research and Development Laboratories, Milan, Italy.

Erratum in

  • Eur J Drug Metab Pharmacokinet 1992 Apr-Jun;17(2):165.

Abstract

The comparative pharmacokinetics of Silipide (IdB 1016, a silybin-phosphatidylcholine complex) and silybin were investigated by measuring unconjugated and total plasma silybin levels as well as total biliary and urinary silybin excretion in rats following administration of a single oral dose (200 mg/kg as silybin). Mean peak levels of unconjugated and total silybin after IdB 1016 were 8.17 and 74.23 micrograms/ml respectively. Mean AUC (0-6 h) values were 9.78 and 232.15 h.micrograms.ml-1 indicating that about 94% of the plasma silybin is present in a conjugated form. After administration of silybin, plasma levels of both unconjugated and total compound were under the analytical detection limit. Cumulative biliary (0-24 h) and urinary (0-72 h) excretion values after administration of IdB 1016 accounted for 3.73% and 3.26% of the administered dose, respectively. After silybin administration, the biliary and urinary excretion accounted for only 0.001% and 0.032% of the dose respectively. Our results indicate a superior bioavailability of silybin administered orally as IdB 1016. This was due mainly to an impressive increase in gastrointestinal absorption.

PMID:
1499596
DOI:
10.1007/BF03189986
[Indexed for MEDLINE]

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