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Planta Med. 2004 Feb;70(2):171-3.

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata.

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1
Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Kwangjin-gu, Seoul, Korea.

Abstract

A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one ( 1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

PMID:
14994197
DOI:
10.1055/s-2004-815496
[Indexed for MEDLINE]
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