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J Gen Virol. 2004 Mar;85(Pt 3):609-13.

Vaccine potential of a murine gammaherpesvirus-68 mutant deficient for ORF73.

Author information

1
Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

Abstract

A murine gammaherpesvirus (MHV-68) containing a deletion of the putative plasmid maintenance protein ORF73 exhibits a severe latency deficit. In this study the ability of an ORF73 deletion mutant (Delta73) to confer in vivo protection against subsequent challenge with wild-type virus has been examined. Vaccination studies have shown that Delta73 vaccination reduced latent infection of wild-type challenge virus to a level below the limit of detection. These results indicate that a live-attenuated gammaherpesvirus that cannot persist is an effective vaccine.

PMID:
14993644
DOI:
10.1099/vir.0.19760-0
[Indexed for MEDLINE]

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