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Mol Interv. 2003 May;3(3):127-30.

Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.

Author information

1
Groupe Cycle Cellulaire, UMR6061 CNRS-Université de Rennes 1, Faculté de Médecine, 2 Avenue du Pr Léon Bernard CS 34317, 35043 Rennes cedex, France. stephanie.dutertre@univ-rennes1.fr

Abstract

The amplification of AURORA-A is frequently observed in specific epithelial cell malignancies. The overexpression of aurora-A, a Ser-Thr kinase known to localize to centrosomes during mitosis, appears to imbue cancerous cells with resistance to spindle-checkpoint-targeting drugs such as paclitaxel (Taxol). Indeed, a recent publication by Anand et al. indicates that overexpression of AURORA-A may interfere with spindle-microtubule attachment and disrupt the regulation of the spindle checkpoint by allowing cells with abnormal chromosomal separation to enter anaphase. Thus, the design of new drugs that specifically target aurora-A rather than other checkpoint proteins might alleviate the resistance to Taxol-like clinical therapeutics observed in some tumors.

PMID:
14993419
DOI:
10.1124/mi.3.3.127
[Indexed for MEDLINE]

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