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World J Gastroenterol. 2004 Mar 1;10(5):672-5.

Relationship of gastric Helicobacter pylori infection to Barrett's esophagus and gastro-esophageal reflux disease in Chinese.

Author information

1
Department of Gastroenterology, Second Hospital, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. jun3z@163.com

Abstract

AIM:

To evaluate the relationship of Helicobacter pylori infection to reflux esophagitis (RE), Barrett's esophagus (BE) and gastric intestinal metaplasia (IM).

METHODS:

RE, BE and gastric IM were determined by upper endoscopy. Patients were divided into 2 groups; those with squamocolumnar junction (SCJ) beyond gastroesophageal junction (GEJ) > =3 cm (group A), and those with SCJ beyond GEJ <3 cm (group B). Biopsy specimens were obtained endoscopically from just below the SCJ, gastric antrum along the greater and lesser curvature. Pathological changes and H pylori infection were determined by HE staining, Alcian blue staining and Giemsa staining.

RESULTS:

The prevalence of H pylori infection was 46.93%. There was no difference in the prevalence between males and females. The prevalence of H pylori infection decreased stepwise significantly from RE grade I to III. There was no difference in the prevalence between the two groups, and between long-segment and short-segment BE. In distal stomach, prevalence of H pylori infection was significantly higher in patients with IM than those without IM.

CONCLUSION:

There is a protective role of H pylori infection to GERD. There may be no relationship between H pylori infection of stomach and BE. H pylori infection is associated with the development of IM in the distal stomach.

PMID:
14991936
PMCID:
PMC4716907
DOI:
10.3748/wjg.v10.i5.672
[Indexed for MEDLINE]
Free PMC Article

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