Format

Send to

Choose Destination
Eur J Immunol. 2004 Mar;34(3):623-630. doi: 10.1002/eji.200324799.

Neuropilin-1: a surface marker of regulatory T cells.

Author information

1
Department of Cell Biology and Immunology, German Research Centre for Biotechnology, Braunschweig, Germany.
2
Department of Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
3
Department of Dermatology, University of Münster, Münster, Germany.
4
Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
5
Institute of Medical Microbiology, Hannover Medical School, Hannover, Germany.

Erratum in

  • Eur J Immunol. 2004 May;34(5):1498.

Abstract

CD4+CD25+ regulatory T cells (Treg cells) control immune responsiveness to a large variety of antigens. The isolation and therapeutic manipulation of Treg cells requires the use of reliable surface receptors that are selectively up-regulated in Treg cells. On the basis of global gene expression studies, we identified neuropilin-1 (Nrp1) as a specific surface marker for CD4+CD25+ Treg cells. Nrp1, a receptor involved in axon guidance, angiogenesis, and the activation of T cells, is constitutively expressed on the surface of CD4+CD25+ Treg cells independently of their activation status. In contrast, Nrp1 expression is down-regulated in naive CD4+CD25- T cells after TCR stimulation. Furthermore, CD4+Nrp1(high) T cells express high levels of Foxp3 and suppress CD4+CD25- T cells. Thus, Nrp1 constitutes a useful surface marker to distinguish Treg cells from both naive and recently activated CD4+CD25+ non-regulatory T cells.

PMID:
14991591
DOI:
10.1002/eji.200324799
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center