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Farmaco. 2004 Mar;59(3):195-9.

Antileishmanial activity of a new 8-hydroxyquinoline derivative designed 7-[5'-(3'-phenylisoxazolino)methyl]-8-hydroxyquinoline: preliminary study.

Author information

1
Département de Biologie, Laboratoire de Microbiologie et Biologie Moléculaire, Faculté des Sciences Ben M'sik-Casablanca, Université Hassan II-Mohammedia, Sidi Othmane, Casablanca B.P. 7955, Morocco. dzainaba@yahoo.fr

Abstract

7-[5'-(3'-phenylisoxazolino)methyl]-8-hydroxyquinoline a new synthetic 8-hydroxyquinoline derivative, was found, for the first time, to inhibit the multiplication in vitro of Leishmania tropica, Leishmania major and Leishmania infantum at micromolar concentrations. For each test we calculated a 50% inhibitory concentration (IC50) and the IC50 values found after 48 h are: 0.4 microgram/ml for L. tropica, 0.88 microgram/ml for L. major and 0.62 microgram/ml for L. infantum. As positive control, amphotericin B, a standard antileishmanial drug was used.

PMID:
14987982
DOI:
10.1016/j.farmac.2003.11.001
[Indexed for MEDLINE]

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