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Lancet. 2004 Feb 21;363(9409):631-9.

Diverticular disease of the colon.

Author information

1
Division of Gastroenterology, San Francisco General Hospital, and University of California San Francisco, San Francisco, CA 94110, USA. NStollman@medsfgh.ucsf.edu

Abstract

Colonic diverticulosis refers to small outpouchings from the colonic lumen due to mucosal herniation through the colonic wall at sites of vascular perforation. Abnormal colonic motility and inadequate intake of dietary fibre have been implicated in its pathogenesis. This acquired abnormality is typically found in developed countries, and its prevalence rises with age. Most patients affected will remain entirely asymptomatic; however, 10-20% of those affected can manifest clinical syndromes, mainly diverticulitis and diverticular haemorrhage. As our elderly population grows, we can anticipate a concomitant rise in the number of patients with diverticular disease. Here, we review the incidence, pathophysiology, clinical presentation, and management of diverticular disease of the colon and its complications.

PMID:
14987890
DOI:
10.1016/S0140-6736(04)15597-9
[Indexed for MEDLINE]

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