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Trends Cardiovasc Med. 1998 Aug;8(6):264-9.

Cx43 gap junctions in cardiac development.

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  • 1Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA.


Studies utilizing knockout and transgenic mouse models revealed an important role for connexin 43 (Cx43) gap junctions in cardiac development. This may involve a quantitative requirement for gap junctions in modulating the development of cardiac crest cells. In addition, studies in humans and Xenopus indicate that Cx43 gap junctions also may play a role in regulating heart laterality. Together, these findings indicate that the perturbation of Cx43 function could play a significant role in specific congenital heart malformations.

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