Abstract
An entirely two-directional synthesis of (+/-)-perhydrohistrionicotoxin is presented, utilizing a tandem oxime formation/Michael addition/[3 + 2] cycloaddition as the key step. This approach also constitutes formal syntheses of (+/-)-histrionicotoxin and (+/-)-histrionicotoxin 235A.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amphibian Venoms / chemical synthesis*
-
Amphibian Venoms / chemistry
-
Amphibian Venoms / isolation & purification
-
Animals
-
Anura
-
Crystallography, X-Ray
-
Models, Molecular
-
Molecular Structure
-
Skin / chemistry
-
Stereoisomerism
Substances
-
Amphibian Venoms
-
perhydrohistrionicotoxin