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Curr Biol. 2004 Feb 3;14(3):R129-38.

Regulation of notch signaling activity.

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CNRS UMR 8542, Ecole Normale Supérieure, Paris, France.


Cell-cell signalling mediated by the receptor Notch is used widely across the metazoans to determine cell fate and regulate pattern formation. Notch signals via a conserved regulated intramembrane proteolysis. Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time.

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