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Gynecol Oncol. 2004 Mar;92(3):927-35.

Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer.

Author information

1
Center for Uterine Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, 411-351, South Korea. ssseomd@ncc.re.kr

Abstract

OBJECTIVES:

This study examines whether expression of COX-2 is associated with clinicopathological features and other molecular markers of ovarian cancer.

METHODS:

Sixty-four paraffin-embedded tissue specimens were obtained from patients with ovarian cancer who received cytoreductive surgery and combination chemotherapy. Tissue specimens were subjected to immunohistochemical analysis using antibodies to COX-2, p53, and VEGF.

RESULTS:

Increased COX-2 expression significantly correlated with histologic type (mucinous 5.6% vs. non-mucinous 65.2%, P<0.001). COX-2 expression was also significantly associated with stage, tumor grade, residual disease status, and presence of ascites. COX-2 expression correlated positively with expression of p53 (P=0.006) and VEGF (P=0.025). Although survival was lower in patients with high COX-2 expression than in those without high COX-2 expression (P<0.001), only tumor grade and stage were independent prognostic indicators. In patients with non-mucinous cancer, COX-2 expression correlated with stage (P<0.001) and presence of ascites (P=0.033).

CONCLUSIONS:

Our results suggest that expression of COX-2 in ovarian cancers is specific to histologic type of tumor and is associated with poor clinicopathologic prognostic factors. Expression of COX-2 also correlates well with expression of p53 and VEGF.

PMID:
14984962
DOI:
10.1016/j.ygyno.2003.11.055
[Indexed for MEDLINE]

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