Interferon targeted genes in host defense

Myriam S Kunzi; Paula M Pitha

doi:10.1080/08916930310001605855

Interferon targeted genes in host defense

Autoimmunity. 2003 Dec;36(8):457-61. doi: 10.1080/08916930310001605855.

Authors

Myriam S Kunzi¹, Paula M Pitha

Affiliation

¹ The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD, USA.

PMID: 14984022
DOI: 10.1080/08916930310001605855

Abstract

Type I Interferons (IFN) induce the expression of IFN-stimulated genes (ISG). The products of some of these genes have direct antiviral effects, others are involved in immunoregulation or modulate signaling pathways and gene expression, and others yet are mediators of cell growth and death. Their role in autoimmune diseases has been found to be both beneficial and detrimental.

Publication types

Review

MeSH terms

Animals
Apoptosis*
Autoimmune Diseases / genetics
Autoimmune Diseases / immunology*
Gene Expression Regulation*
Humans
Interferon Inducers
Interferon Type I / biosynthesis
Interferon Type I / pharmacology
Interferon Type I / physiology*
Oligonucleotide Array Sequence Analysis
Receptors, Interferon / physiology*
Recombinant Proteins
Signal Transduction*
Virus Diseases / immunology

Substances

Interferon Inducers
Interferon Type I
Receptors, Interferon
Recombinant Proteins