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Bioorg Med Chem Lett. 2004 Mar 8;14(5):1265-8.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. chuck_caldwell@merck.com

Abstract

Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good pharmacokinetic properties and was orally active in an oral glucose tolerance test in lean mice.

PMID:
14980678
DOI:
10.1016/j.bmcl.2003.12.040
[Indexed for MEDLINE]

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