Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1151-4.

Potent imidazole and triazole CB1 receptor antagonists related to SR141716.

Author information

1
Departments of Medicinal Chemistry, Pharmacology and Molecular Biology, Neurocrine Biosciences Inc., 10555 Science Center Drive, San Diego, CA 92121, USA.

Abstract

Diarylimidazolecarboxamides and diaryltriazolecarboxamides related to SR141716 were synthesized and tested for binding to the human CB(1) receptor. Suitably substituted imidazoles are comparably potent to the clinical candidate, whereas the analogous triazoles are less so due to the absence of an additional substituent on the azole ring.

PMID:
14980654
DOI:
10.1016/j.bmcl.2003.12.068
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center