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Exp Cell Res. 2004 Mar 10;294(1):140-8.

An actin-myosin complex on actively transcribing genes.

Author information

1
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm 171 77, Sweden.

Abstract

Actin and myosin have been individually implicated in different aspects of gene expression. Here, we show in vivo evidence for a specific nucleolar actin-myosin complex physically associated with both the RNA polymerase I holoenzyme and ribosomal genes. We find that this specific actin-myosin complex is functionally coupled to elongating ribosomal RNA transcripts in living cells. From these observations, we conclude that an actin-based myosin motor is associated with transcribing ribosomal genes in the cell nucleus. These results correlate with an involvement of both actin and myosin in regulating mRNA synthesis and suggest that actin-myosin motors may provide a general mechanism to facilitate elongation of RNA transcripts during transcription of both ribosomal genes and protein-coding genes.

PMID:
14980509
DOI:
10.1016/j.yexcr.2003.10.028
[Indexed for MEDLINE]

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