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Curr Opin Cell Biol. 1992 Jun;4(3):496-501.

Signal transduction: the nuclear target.

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Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186-5800.


Fos and jun heterodimers activate the transcription of genes containing an AP-1 site. The activity of Fos and Jun proteins is regulated by post-translational modification. The activity of the rel/NF-kappa family of transcriptional factors is regulated by their sequestration in the cytoplasm in association with the inhibitor protein, I kappa B. An ankyrin repeat motif in I kappa B proteins is required for their direct association with rel/NF-kappa B.

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