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Mov Disord. 2004 Feb;19(2):226-8.

Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD.

Author information

1
Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Abstract

Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.

PMID:
14978683
DOI:
10.1002/mds.10629
[Indexed for MEDLINE]

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