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Jpn Heart J. 2004 Jan;45(1):163-7.

Brugada-like electrocardiographic pattern unmasked by fever.

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Second Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.


Brugada syndrome is characterized by right bundle branch block morphology and ST-segment elevation in the right precordial leads and a propensity to develop ventricular arrhythmias. Mutations in a cardiac sodium channel gene have been linked to this syndrome, and the ionic mechanisms responsible for the electrocardiographic phenotype are temperature-dependent. This case report describes a patient in whom a typical Brugada ECG pattern developed during fever and could be reproduced at normal body temperature by administration of pilsicainide.

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