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Development. 2004 Mar;131(5):965-73.

Notch signaling: control of cell communication and cell fate.

Author information

1
Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA. lai@fruitfly.org

Abstract

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.

PMID:
14973298
DOI:
10.1242/dev.01074
[Indexed for MEDLINE]
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