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Clin Biochem. 2004 Mar;37(3):210-6.

Biochemical indicators of cardiac and renal function in a healthy elderly population.

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Department of Medical Sciences, Cardiology, University Hospital, Uppsala, Sweden.



To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population.


NT-proBNP and cystatin C were analyzed in 407 and 408 healthy individuals, median age: 65 (range 40-76).


Increasing age, female gender and CRP were independently associated to higher NT-proBNP levels. Age, body mass index, and CRP level were independently associated to the cystatin C level. In women and men, < or =65 years, the 97.5th percentile value for NT-proBNP was 268 ng/l and 184 ng/l, in those older, 391 ng/l and 269 ng/l. For those < or =65 years the 97.5th percentile value for cystatin C was 1.12 mg/l, and for those older 1.21 mg/l.


In a healthy elderly population, NT-proBNP is influenced by age and gender, whereas cystatin C is influenced by age but not by gender. Both markers seem to be associated to the CRP level.

[Indexed for MEDLINE]

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