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Arch Phys Med Rehabil. 2004 Jan;85(1):1-6.

Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.

Author information

  • 1Department of Rehabilitation Medicine, University of Washington, Seattle 98104, USA. lorenzo@u.washington.edu

Abstract

OBJECTIVE:

To evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain.

DESIGN:

Randomized controlled trial of amitriptyline for 6 weeks.

SETTING:

University hospital.

PARTICIPANTS:

Thirty-nine persons with amputation-related pain lasting more than 6 months.

INTERVENTION:

Six-week trial of amitriptyline (titrated up to 125 mg/d) or an active placebo (benztropine mesylate).

MAIN OUTCOME MEASURES:

Analyses were conducted to examine whether there was a medication group effect on the primary outcomes (average pain intensity) and secondary outcome measures (disability, satisfaction with life, handicap).

RESULTS:

No significant differences were found between the treatment groups in outcome variables when controlling for initial pain scores.

CONCLUSIONS:

Our findings do not support the use of amitriptyline in the treatment of postamputation pain.

PMID:
14970960
[PubMed - indexed for MEDLINE]
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