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Br J Cancer. 2004 Feb 23;90(4):761-9.

Linking the epigenetic 'language' of covalent histone modifications to cancer.

Author information

1
Laboratory of Chromatin Biology, The Rockefeller University, Box 78, 1230 York Avenue, New York, NY 10021, USA.

Abstract

Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies.

PMID:
14970850
PMCID:
PMC2410168
DOI:
10.1038/sj.bjc.6601575
[Indexed for MEDLINE]
Free PMC Article

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