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Bull Exp Biol Med. 2003 Nov;136(5):448-50.

Immune system in vasopressin-deficient rats during ontogeny.

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Laboratory of Physiological Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.


Morphofunctional immune disorders were revealed in vasopressin-deficient Brattleboro rats with diabetes insipidus during ontogeny. We observed a permanent decrease in the number of blood lymphocytes, increase in neutrophil count, reduced activity of macrophages, early involution of the thymus and spleen, and suppression of antibody production. These changes reflect impaired general resistance of these animals.

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