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EMBO Rep. 2004 Mar;5(3):274-9. Epub 2004 Feb 13.

Convergent evolution of gene networks by single-gene duplications in higher eukaryotes.

Author information

1
School of Biological Sciences, University of Manchester, UK.

Abstract

By combining phylogenetic, proteomic and structural information, we have elucidated the evolutionary driving forces for the gene-regulatory interaction networks of basic helix-loop-helix transcription factors. We infer that recurrent events of single-gene duplication and domain rearrangement repeatedly gave rise to distinct networks with almost identical hub-based topologies, and multiple activators and repressors. We thus provide the first empirical evidence for scale-free protein networks emerging through single-gene duplications, the dominant importance of molecular modularity in the bottom-up construction of complex biological entities, and the convergent evolution of networks.

PMID:
14968135
PMCID:
PMC1299007
DOI:
10.1038/sj.embor.7400096
[Indexed for MEDLINE]
Free PMC Article

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