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Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):927-31.

The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: a review of preclinical and correlative clinical data.

Author information

1
Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. achakravarti@partners.org

Abstract

PURPOSE:

The epidermal growth factor receptor (EGFR) pathway is frequently upregulated in high-grade gliomas via gene amplification and by specific mutations that render EGFR constitutively active (EGFRvIII).

METHODS AND MATERIALS:

This review highlights EGFR's role in mediating radiation resistance in gliomas: underlying molecular mechanisms, with discussion of relevant preclinical and clinical correlative data.

RESULTS:

Preclinical and emerging clinical data suggest that EGFR signaling plays a potentially important role in mediating radiation resistance in human gliomas.

CONCLUSIONS:

Targeting EGFR alone, or in combination with its downstream mediators, represents a promising new approach for the management of glioma patients.

PMID:
14967452
DOI:
10.1016/j.ijrobp.2003.09.092
[Indexed for MEDLINE]

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