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Fertil Steril. 2004 Feb;81(2):337-41.

AZF microdeletions of the Y chromosome and in vitro fertilization outcome.

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1
Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA.

Abstract

OBJECTIVE:

To determine whether the presence of a Y microdeletion confers any adverse effects on in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) outcome.

DESIGN:

Retrospective case-control study.

SETTING:

Academic infertility center.

PATIENT(S):

A total of 17 patients with Y microdeletions who attempted IVF/ICSI cycles at our center between March 1996 and March 2002 were studied. Study patients were analyzed in two groups: those who underwent testicular sperm extraction (TESE) and those for whom ejaculated sperm was used.

INTERVENTION(S):

The two patient study groups were matched to controls treated at the same time who had either nonobstructive severe oligozoospermia or azoospermia with normal Y chromosomes. Controls were matched for age of the female partner, sperm concentration, and number of embryos transferred.

MAIN OUTCOME MEASURE(S):

Fertilization and clinical pregnancy rates.

RESULT(S):

Sperm was only obtained from patients with azoospermic factor (AZF)c microdeletions (and from one patient with a partial AZFb microdeletion). A trend toward lower fertilization rates in patients with Y microdeletions was noted, which did not reach statistical significance. Clinical pregnancy rates per cycle and per transfer were similar to those for controls.

CONCLUSION(S):

Patients with AZFc microdeletions seem to have IVF/ICSI outcomes comparable to those of controls with normal Y chromosomes.

[Indexed for MEDLINE]
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