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Mol Cell. 2004 Feb 13;13(3):302-4.

A protein interaction domain contacts RNA in the prespliceosome.

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Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 USA.


SR proteins bind to exons and recruit the spliceosome via protein interactions mediated by an arginine-serine-rich (RS) domain. In this issue of Molecular Cell, demonstrate that the RS domain of SR proteins contacts the pre-mRNA branchpoint, indicating that these domains participate in both protein and RNA interactions.

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