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Transplantation. 2004 Feb 15;77(3):475-7.

Toll-like receptor-4 and allograft responses.

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Transplantation Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.


Signaling through toll-like receptors (TLRs) is believed to be the critical first step in the activation of antigen presenting cells and the initiation of adaptive immune responses. Of these receptors, TLR-4 particularly recognizes endogenous agonists and may be important for allograft responses. We tested this concept using mice with defective function and structure of TLR-4 as recipients of grafts across major and minor histocompatibility barriers. The kinetics of rejection was the same in mutant mice and wild-type controls. Our results highlight an important difference between alloimmune and conventional immune responses.

[Indexed for MEDLINE]

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