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Ann Pharmacother. 2004 Apr;38(4):705-9. Epub 2004 Feb 13.

Oral antivirals for the acute treatment of recurrent herpes labialis.

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1
College of Pharmacy, University of Iowa, Iowa City, IA, USA.

Abstract

OBJECTIVE:

To evaluate the use and benefit of oral antivirals in the acute treatment of episodic, recurrent herpes labialis.

DATA SOURCES:

A literature search was performed in MEDLINE (1966-August 2003) using acyclovir, famciclovir, valacyclovir, cold sores, herpes labialis, and HSV-1 as search terms.

DATA SYNTHESIS:

We reviewed 5 placebo-controlled and 2 comparative studies evaluating oral antivirals for acute treatment of recurrent herpes labialis. No studies directly compared different antivirals. Studies discussing the efficacy of antivirals for chronic suppression of herpes simplex virus-1 infection were not included.

CONCLUSIONS:

Treatment with oral antivirals decreases the duration of lesion episodes and pain by approximately one day; however, the antivirals do not abort lesions from developing. Clinical implications of these results appear relatively modest.

PMID:
14966254
DOI:
10.1345/aph.1D285
[Indexed for MEDLINE]
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