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Eur J Dermatol. 2004 Jan-Feb;14(1):13-8.

CLA(+) T cells in cutaneous diseases.

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1
Almirall Prodesfarma, Research Center, Cardener, 68-74, 08024 Barcelona, Spain. Lsantama@almirallprodesfarma.com

Abstract

The Cutaneous Lymphocyte-associated Antigen (CLA) was originally described as a cell surface molecule preferentially found on T lymphocytes present in the skin. At the present time, a more complete and exciting picture is emerging thanks to the efforts of different research groups. The CLA antigen identifies a subset of memory effector T lymphocytes functionally involved in the pathogenesis of different T cell-mediated cutaneous diseases. Research related to CLA(+ )T cells is not only becoming a source of interesting data related to the pathological mechanisms of skin disorders, but also provides an innovative and selective approach to develop new treatments for T cell-mediated diseases in dermatology.

PMID:
14965789
[Indexed for MEDLINE]
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