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Trends Genet. 1992 Jun;8(6):193-7.

Telomere positional effects and the regulation of cellular senescence.

Author information

1
Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235-9039.

Abstract

Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes--telomeres--have been shown to shorten progressively with age in normal cells. Here, we present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

PMID:
1496553
DOI:
10.1016/0168-9525(92)90232-s
[Indexed for MEDLINE]

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