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Fiziol Zh. 2003;49(6):80-93.

[Bile acids in the process of canalicular bile formation].

[Article in Ukrainian]

Author information

1
Institute of Physiology of Biology Faculty of Taras Shevchenko, National Kiev University.

Abstract

This review summarizes the current knowledge of the role of bile acid in the canalicular bile secretion: its membrane transport in hepatocyte; molecular mechanisms and pathways of its regulatory effects on membrane transporters; the role of its hydrophobicity in membrane transporter regulation; hepatocyte necrosis and apoptosis at cholestasis induced by hydrophobic bile acids; the possible mechanisms of protective effects of ursodeoxycholic acid in cholestatic impairment of the liver.

PMID:
14965044
[Indexed for MEDLINE]
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