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Bioinformatics. 2004 Jul 22;20(11):1795-6. Epub 2004 Feb 12.

A general computational model of mitochondrial metabolism in a whole organelle scale.

Author information

1
Institute for Advanced Biosciences, Keio University, Endo 5322, Fujisawa, Kanagawa, 252-8520, Japan.

Abstract

A computational tool for mitochondrial systems biology has been developed as a simulation model of E-Cell2, a publicly available simulation system. The general model consists of 58 enzymatic reactions and 117 metabolites, representing the respiratory chain, the TCA cycle, the fatty acid beta-oxidation and the inner-membrane transport system. It is based on previously published enzyme kinetics studies in the literature; we have successfully integrated and packaged them into a single large model. The model can be easily extended and modified so that mitochondrial biologists/physiologists can integrate their own models and evaluate them in the context of the whole organelle metabolism.

AVAILABILITY:

The mitochondrial model is bundled up with E-Cell2 simulation system, which can be downloaded from http://www.e-cell.org. CD-ROMs are also available and are distributed at major conferences.

SUPPLEMENTARY INFORMATION:

All the kinetic data are available via http://www.e-cell.org

PMID:
14962921
DOI:
10.1093/bioinformatics/bth125
[Indexed for MEDLINE]

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