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FEBS Lett. 2004 Feb 13;559(1-3):39-44.

The C-terminal region as a modulator of rNa(v)1.7 and rNa(v)1.8 expression levels.

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Laval University, Department of Medicine, and Laval Hospital, Research Centre, 2725 chemin Sainte-Foy, Sainte-Foy, QC, Canada G1V 4G5.


Mammalian cells poorly express rNa(v)1.8 channels. In contrast, rNa(v)1.7 dorsal root ganglion channels have 90-fold higher peak Na(+) current densities. We investigated the role of rNa(v)1.7 and rNa(v)1.8 carboxy-termini in modulating the expression of rNa(v)1.7 and rNa(v)1.8 channels in tsA201 cells. Mutations in the ubiquitination site of the C-terminus did not improve rNa(v)1.8 current levels. However, rNa(v)1.8 chimeras containing the entire or the proximal portion of the rNa(v)1.7 C-terminus expressed 3.2-fold and 4.8-fold higher peak current densities, respectively, than parent rNa(v)1.8 channels. We conclude that the two Na(+) channels may have different endoplasmic reticulum processing signals.

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