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Dev Cell. 2004 Feb;6(2):167-81.

Early steps in the development of the forebrain.

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Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom.


The tremendous complexity of the adult forebrain makes it a challenging task to elucidate how this structure forms during embryonic development. Nevertheless, we are beginning to understand how a simple epithelial sheet of ectoderm gives rise to the labyrinthine network of cells that constitutes the functional forebrain. Here, we discuss early events in forebrain development--those that lead to the establishment of the anterior neural plate and the regional subdivision of this territory into the different domains of the prospective forebrain.

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