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Immunology. 1992 Dec;77(4):624-6.

Hydrocortisone inhibition of human interleukin-4.

Author information

1
Department of Biochemistry, Royal Melbourne Hospital, Parkville, Victoria, Australia.

Abstract

Glucocorticoids are known to inhibit mitogen-induced proliferation of T cells by suppressing the production of interleukin-2 (IL-2). These hormones have also been shown to inhibit the production of other cytokines, namely IL-1 and interferon-gamma (IFN-gamma). It is demonstrated here that hydrocortisone is able to inhibit mitogen-induced production of human IL-4, both at the secreted protein, as well as at the mRNA level. This effect may explain, in part, the immunosuppressive effects of glucocorticoids in the treatment of allergic disease.

PMID:
1493933
PMCID:
PMC1421657
[Indexed for MEDLINE]
Free PMC Article

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