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Leuk Lymphoma. 1992 Sep;8(1-2):75-9.

Extremely poor prognosis of pediatric acute lymphoblastic leukemia with translocation (9;22): updated experience.

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1
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.

Abstract

Approximately five percent of pediatric acute lymphoblastic leukemias (ALL) contain a translocation (9;22)(q34;q11) which results in rearrangement of the bcr and abl genes. At a median follow-up of 5 years, we assessed the prognostic implications of translocation (9;22) in 434 children receiving intensive treatment for ALL. Four-year event-free and overall survivals were only 0% and 20%, respectively, in 15 children with translocation (9;22), but were 81% and 89%, respectively, in 419 children lacking translocation (9;22) (P < 0.001). Based on these findings, we recommend very intensive treatment approaches for all children with translocation (9;22)-positive ALL.

PMID:
1493473
DOI:
10.3109/10428199209049820
[Indexed for MEDLINE]
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