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Trends Genet. 1992 Dec;8(12):452-7.

Antigenic variation in African trypanosomes.

Author information

1
Department of Genetics and Molecular Biology, Merck Research Laboratories, Rahway, NJ 07065.

Abstract

African trypanosomes evade the humoral immune response by periodically changing the antigenic identity of their variant cell-surface glycoprotein (VSG) coat. Antigenic variation relies on DNA rearrangement events that can translocate a silent VSG gene to a telomerically located VSG gene expression site. Antigenic switches can also be brought about by the differential transcriptional control of the expression sites, only one of which is transcribed at any time.

PMID:
1492370
DOI:
10.1016/0168-9525(92)90330-7
[Indexed for MEDLINE]

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