Format

Send to

Choose Destination
Trends Genet. 1992 Dec;8(12):446-52.

Mating-type gene switching in Saccharomyces cerevisiae.

Author information

1
Rosenstiel Center, Brandeis University, Waltham, MA 02254.

Abstract

The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also provided an opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors.

PMID:
1492369
DOI:
10.1016/0168-9525(92)90329-3
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center