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Neuropathol Appl Neurobiol. 1992 Dec;18(6):539-47.

Allocortical involvement in Huntington's disease.

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Department of Anatomy, J.W. Goethe University of Frankfurt, Germany.


Seven brains of individuals who had suffered from Huntington's disease and seven control brains were examined. Preparations stained for Nissl material and lipofuscin pigment revealed a characteristic layer-specific loss of nerve cells in two allocortical areas, the entorhinal region and the subiculum. The most severe changes occurred in the entorhinal layer Pri-gamma while layer Pre-alpha, layer Pre-gamma and the subiculum showed less severe alterations.

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