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J Clin Psychiatry. 1992 Dec;53(12):439-42.

Emergence of obsessive compulsive symptoms during treatment with clozapine.

Author information

1
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213.

Abstract

BACKGROUND:

Clozapine differs from other currently available antipsychotics in its prominent serotonin blockade. We explore the relationship between clozapine and obsessive compulsive symptoms, which have been linked to deficient serotonin.

METHOD:

We reviewed our experience in treating 49 chronic schizophrenic patients with clozapine.

RESULTS:

Five patients were identified who experienced either de novo obsessive compulsive symptoms or exacerbation of preexistent symptoms. Clinical details are provided for each case.

CONCLUSION:

Clozapine may produce or unmask obsessive compulsive symptoms. This may reflect a variation on the normal course of clinical improvement, or may more specifically result from clozapine's atypical pattern of CNS receptor antagonism. Further attention to this issue is warranted.

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PMID:
1487472
[Indexed for MEDLINE]

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