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Biochim Biophys Acta. 2004 Feb 12;1696(2):223-33.

Proteinaceous inhibitors of endo-beta-glucanases.

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1
Department of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, 220 Riverbend Road, Athens, GA 30602-4712, USA. will@ccrc.uga.edu

Abstract

Both plants and filamentous phytopathogens secrete proteins that inhibit endo-beta-glucanases. The first endo-beta-glucanase inhibitor proteins to be discovered are XEGIP, a tomato protein that inhibits fungal xyloglucan-specific endo-beta-1,4-glucanases, and GIP1, an oomycete protein that inhibits endo-beta-1,3-glucanases produced by the plant host. These inhibitor proteins act by forming high-affinity complexes with their endoglucanase ligands. A family of XEGIP-like proteins has been identified. At least one member of this family (extracellular dermal glycoprotein, EDGP) has been shown to have endoglucanase-inhibitor activity, while other members have sequence similarity to a xylanase inhibitor from wheat (TAXI-1). The oomycete inhibitor GIP1 is a catalytically inactive serine protease homolog (SPH) whose structure is unrelated to XEGIP. Both types of inhibitor proteins are likely to affect the interactions of plants with filamentous phytopathogens, and a basic model describing their roles in pathogenesis is proposed.

PMID:
14871663
DOI:
10.1016/j.bbapap.2003.07.003
[Indexed for MEDLINE]
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